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Related Experiment Videos

Integrated chip-based capillary electrophoresis

C S Effenhauser1, G J Bruin, A Paulus

  • 1Novartis Pharma AG, Bioanalytical Research, Basel, Switzerland. carlo_stefan.effenhauser@pharma.novartis.com

Electrophoresis
|February 10, 1998
PubMed
Summary

Integrated capillary electrophoresis (ICE) offers fast, automated assays for pharmaceutical drug development. This review details ICE

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Area of Science:

  • Analytical Chemistry
  • Biotechnology
  • Pharmaceutical Science

Background:

  • Integrated capillary electrophoresis (ICE) is an emerging analytical technology.
  • ICE offers advantages such as speed, automation, miniaturization, and multiplexing.
  • These features align with the demands of pharmaceutical drug development.

Purpose of the Study:

  • To review the current state-of-the-art in Integrated Capillary Electrophoresis (ICE).
  • To highlight key considerations for ICE implementation, including support materials, fluid handling, and detection.
  • To present various strategies and chip designs for advanced ICE applications.

Main Methods:

  • Review of current literature and technological advancements in ICE.
  • Emphasis on material science for support substrates (glass vs. polymers).
  • Discussion of electrokinetic principles for fluid manipulation and sample introduction/detection.

Main Results:

  • ICE technology is advancing rapidly, offering significant improvements over traditional methods.
  • Specific strategies for derivatization, DNA sequencing, PCR, enzymatic digestion, and immunoassays are detailed.
  • Various chip designs facilitate diverse analytical workflows on a single platform.

Conclusions:

  • ICE is a powerful tool for pharmaceutical research and drug development.
  • Continued innovation in materials and chip design will further enhance ICE capabilities.
  • ICE is poised to become a standard analytical technique in the pharmaceutical industry.

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