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Updated: Jul 27, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Factor V Leiden mutation in a case with ischemic stroke: which relationship? A case report
G Orlandi1, A Pellegrinetti, C Fioretti
1Department of Neurosciences, University of Pisa, Italy.
Angiology
|February 10, 1998
Summary
A 50-year-old man experienced an internal carotid artery dissection and ischemic stroke. This case explores a potential link between Factor V Leiden mutation-related clotting disorder and stroke occurrence in patients lacking other vascular risks.
Area of Science:
- Neurology
- Vascular Medicine
- Hematology
Background:
- Spontaneous internal carotid artery dissection is a rare cause of ischemic stroke.
- Factor V Leiden mutation is a known risk factor for venous thromboembolism but its association with arterial dissection and stroke is less understood.
Observation:
- A 50-year-old male patient presented with spontaneous internal carotid artery dissection and subsequent ischemic stroke.
- The patient had a documented history of deep venous thrombosis.
- An activated protein C resistance, attributed to the Factor V Leiden mutation, was identified.
- No other conventional vascular risk factors were present in the patient.
Findings:
- The case highlights an unusual presentation of ischemic stroke secondary to internal carotid artery dissection.
- The presence of Factor V Leiden mutation and a history of deep venous thrombosis in the absence of other risk factors raises questions about its role in arterial events.
Implications:
- This case suggests a potential association between Factor V Leiden mutation and spontaneous arterial dissection leading to ischemic stroke.
- Further research is warranted to elucidate the mechanisms linking inherited thrombophilias to arterial cerebrovascular events.
- Understanding such associations could refine risk stratification and management strategies for stroke prevention in specific patient populations.
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