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Related Concept Videos

Autoxidation of Ethers to Peroxides and Hydroperoxides02:23

Autoxidation of Ethers to Peroxides and Hydroperoxides

Ethers represent a class of chemical compounds that become more dangerous with prolonged storage because they tend to form explosive peroxides when standing in the air. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly oxidize to form hydroperoxides and dialkyl peroxides.
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The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
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Updated: Jul 28, 2026

In vitro Cell Culture Model for Toxic Inhaled Chemical Testing
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Tetrachloroethylene intoxication in an autoerotic fatality

D S Isenschmid1, B J Cassin, B R Hepler

  • 1Office of the Wayne County Medical Examiner, Detroit, MI, USA.

Journal of Forensic Sciences
|February 11, 1998
PubMed
Summary

Accidental death occurred from inhaling tetrachloroethylene (a tire sealant chemical) during an autoerotic episode. High blood concentrations confirmed acute intoxication.

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Area of Science:

  • Forensic Toxicology
  • Environmental Health

Background:

  • Autoerotic practices carry inherent risks.
  • Tetrachloroethylene is a volatile solvent found in some consumer products.

Observation:

  • A case report details an accidental fatality.
  • The individual inhaled tetrachloroethylene from a tire repair product during an autoerotic act.

Findings:

  • Blood analysis revealed a tetrachloroethylene concentration of 62 mg/L.
  • This level is indicative of acute tetrachloroethylene intoxication.

Implications:

  • Highlights the dangers of volatile solvent misuse.
  • Underscores the importance of product safety and awareness.
  • Informs forensic investigations involving solvent exposure.