Related Experiment Videos
The deep mycoses in HIV infection
C Scully1, O P de Almeida, M R Sposto
1Eastman Dental Institute and Hospital for Oral Health Care Sciences, London, UK.
Oral Diseases
|May 1, 1997
Summary
Deep mycoses are uncommon fungal infections often seen in immunocompromised individuals, including those with HIV. Diagnosis involves biopsy and culture, with amphotericin or azoles as primary treatments.
Area of Science:
- Mycology
- Infectious Diseases
- Immunocompromised Host
Background:
- Deep mycoses are uncommon fungal infections acquired through spore inhalation/ingestion.
- These infections occur in endemic areas (Americas, SE Asia) or from decaying matter.
- They increasingly affect immunocompromised individuals, particularly those with HIV.
Purpose of the Study:
- To summarize the epidemiology, clinical presentation, diagnosis, and treatment of deep mycoses.
- To highlight the orofacial manifestations in HIV-infected patients.
Main Methods:
- Review of literature on deep mycoses.
- Analysis of common pathogens and their characteristics.
Main Results:
- Respiratory and mucocutaneous involvement are frequent, with granulomas.
- Oral lesions are chronic, non-specific, often nodular or ulcerative.
- Histoplasmosis, cryptococcosis, aspergillosis, and zygomycosis are common in HIV disease.
- Diagnosis relies on biopsy and culture.
- Treatment involves amphotericin or azoles.
Conclusions:
- Deep mycoses require prompt diagnosis and treatment, especially in immunocompromised patients.
- Understanding orofacial manifestations is crucial for early detection in HIV patients.