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Vinyl chloride-associated liver disease

P D Berk, J F Martin, R S Young

Annals of Internal Medicine

|June 1, 1976

Summary

This summary is machine-generated.

Vinyl chloride polymerization workers face serious health risks, including liver disease and cancers. Exposure can lead to hepatic fibrosis and angiosarcoma, similar to arsenic poisoning.

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Area of Science:

Occupational Health
Toxicology
Hepatology

Background:

Polyvinyl chloride production involves vinyl chloride monomer (VCM).
Worker exposure to VCM has been recognized as a health hazard since the mid-1960s.

Observation:

Workers cleaning polymerization tanks showed acro-osteolysis in the 1960s.
In 1974, this population exhibited increased risk for hepatic fibrosis and angiosarcoma.

Findings:

Two cases of vinyl chloride-associated liver injury are presented: hepatic fibrosis and angiosarcoma.
Histological similarities exist between VCM-induced lesions and those from inorganic arsenical exposure.
VCM toxicity may stem from active metabolites formed by liver mixed-function oxidases during high-dose exposure.

Implications:

Vinyl chloride exposure is linked to increased incidence of liver disease.
Epidemiological data suggest elevated risks for brain, lung, and other cancers in exposed workers.