Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine receptors: from structure to function

C Missale1, S R Nash, S W Robinson

  • 1Department of Cell Biology, Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, North Carolina, USA.

Physiological Reviews
|February 11, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential effect of acute reserpine administration on D-1 and D-2 dopaminergic receptor density and function in rat striatum.

Neurochemistry international·2010
Same author

Gene expression profile of prostate cancer cell lines: effect of nerve growth factor treatment.

Molecular and cellular endocrinology·2008
Same author

Oligomeric assembly of dopamine D1 and glutamate NMDA receptors: molecular mechanisms and functional implications.

Biochemical Society transactions·2004
Same author

Sex-related variations in serum nerve growth factor concentration in humans.

Neuropeptides·2003
Same author

Retinoic acid prevents experimental Cushing syndrome.

The Journal of clinical investigation·2001
Same author

Genetic animal models: focus on schizophrenia.

Trends in neurosciences·2001
Same journal

Long-term potentiation in the brain: A synaptic memory mechanism.

Physiological reviews·2026
Same journal

Catecholamine metabolism revisited: From neurochemistry to integrative physiology and pathophysiology.

Physiological reviews·2026
Same journal

THE ORIGINS AND PROGRESSION OF PYLORIC METAPLASIA FOLLOWING GASTRIC MUCOSAL INJURY.

Physiological reviews·2026
Same journal

AKAP signaling: physiological and pathophysiological roles and opportunities for novel therapeutic concepts.

Physiological reviews·2026
Same journal

Mechanisms of transcranial magnetic brain stimulation.

Physiological reviews·2026
Same journal

Esophageal peristalsis in health and disease: mechanistic insights.

Physiological reviews·2026
See all related articles

Dopamine receptors, crucial for brain and body functions, are classified into D1-like and D2-like families. Research explores their roles in health and disease, with mouse models aiding further understanding.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Dopamine receptors are G protein-coupled receptors mediating diverse physiological actions.
  • Five subtypes exist: D1-like (D1, D5) activating adenylyl cyclase, and D2-like (D2, D3, D4) inhibiting it and activating K+ channels.
  • Receptor gene structures vary, with D1/D5 being intronless and D2/D3/D4 exhibiting alternative splicing and polymorphism.

Purpose of the Study:

  • To review the classification, signaling, genetic characteristics, and physiological roles of dopamine receptor subtypes.
  • To highlight their expression in the central nervous system and periphery.
  • To discuss the challenges in linking receptor genes to central nervous system disorders and the potential of genetic deletion studies.

Main Methods:

  • Literature review of dopamine receptor subtypes.

Related Experiment Videos

  • Analysis of receptor signaling pathways (Gs/Gi proteins, adenylyl cyclase, K+ channels).
  • Examination of gene structures, alternative splicing, and genetic variation.
  • Review of physiological functions in CNS and periphery.
  • Discussion of genetic linkage studies and gene deletion models.

    • Main Results:

    • Dopamine receptors are categorized into D1-like and D2-like families with distinct signaling pathways.
    • Widespread CNS expression impacts locomotion, cognition, emotion, and neuroendocrine functions.
    • Peripheral expression affects sodium homeostasis, vascular tone, and hormone secretion.
    • Genetic studies have not yet definitively linked specific receptors to CNS disorders.

    Conclusions:

    • Dopamine receptor subtypes possess diverse signaling and physiological roles.
    • Understanding these receptors is crucial for neuroscience and pharmacology.
    • Future research, including gene deletion studies in mice, is essential for elucidating their precise functions and roles in disease.