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Lobular carcinoma in situ with microinvasion
T Nemoto1, N Castillo, Y Tsukada
1Department of Surgery, Sisters of Charity Hospital, Buffalo, New York, USA.
Journal of Surgical Oncology
|February 11, 1998
Summary
Lobular carcinoma in situ with microinvasion is a rare finding that challenges current understanding. This suggests lobular carcinoma in situ may not solely be a marker but could potentially progress to microinvasive disease.
Area of Science:
- Oncology
- Pathology
- Breast Cancer Research
Background:
- Lobular carcinoma in situ (LCIS) is traditionally considered a non-obligate precursor to invasive breast cancer.
- Current understanding posits LCIS as a marker for increased risk of subsequent invasive disease.
Observation:
- This report details six cases of lobular carcinoma in situ with concurrent microinvasion.
- The presence of microinvasion alongside LCIS is an infrequently observed phenomenon.
Findings:
- The co-occurrence of lobular carcinoma in situ and microinvasion suggests a potential, albeit rare, progression pathway.
- This finding necessitates a re-evaluation of the established biological behavior of LCIS.
Implications:
- The traditional view of LCIS as purely a risk marker may require revision.
- Further research is warranted to understand the mechanisms and frequency of LCIS progression to microinvasive disease.