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Rational interleukin-2 therapy
1Immunology Program, Graduate School of Medical Sciences, Cornell University, USA.
The administration of cytokines that augment the function of the immune system can be accomplished safely and without toxicity, provided a rational approach is used. Such a therapeutic method should be based upon the principles of pharmacology and the structure-activity relationships of the cytokine-receptor interaction. Thus, the therapeutic index should be determined, and the goal should be to augment the function of the immune system in a variety of clinical situations, not necessarily focused on eradicating a particular disease process such as metastatic cancer that may or may not be influenced by the immune system.
The administration of cytokines that augment the function of the immune system can be accomplished safely and without toxicity, provided a rational approach is used. Such a therapeutic method should be based upon the principles of pharmacology and the structure-activity relationships of the cytokine-receptor interaction. Thus, the therapeutic index should be determined, and the goal should be to augment the function of the immune system in a variety of clinical situations, not necessarily focused on eradicating a particular disease process such as metastatic cancer that may or may not be influenced by the immune system.