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Third ventricular glioblastoma multiforme: case report
1Department of Neurological Surgery, University of Miami School of Medicine, Florida, USA.
Abstract:
Intraventricular neoplasms of the third ventricle represent a small minority of intracranial tumors. Furthermore, few cases of solitary, third ventricular glioblastoma multiforme were reported in the literature. The authors report a case of a fifty-nine year old man who presented with progressive gait disturbance, disorientation, diffuse headache, and vomiting. Computed tomography and magnetic resonance imaging (MRI) confirmed a solitary third ventricular ring-enhancing lesion and obstructive hydrocephalus. The final pathology of the lesion upon permanent section was glioblastoma multiforme (GBM). The clinical course, radiologic findings, the possible origin of this lesion, as well as possible treatment regimen are discussed.
Insights
A rare solitary glioblastoma multiforme (GBM) in the third ventricle caused obstructive hydrocephalus and neurological symptoms in a 59-year-old man. This case highlights the importance of considering rare intraventricular neoplasms in differential diagnoses.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Neuropathology
Background:
- Intraventricular neoplasms are rare intracranial tumors, with solitary third ventricular lesions being exceptionally uncommon.
- Glioblastoma multiforme (GBM) typically occurs as a supratentorial tumor, making its presentation within the third ventricle a rare occurrence.
Observation:
- A 59-year-old male presented with progressive gait disturbance, disorientation, headache, and vomiting.
- Radiological imaging (CT and MRI) revealed a solitary, ring-enhancing lesion in the third ventricle causing obstructive hydrocephalus.
Findings:
- Histopathological examination of the resected lesion confirmed the diagnosis of glioblastoma multiforme (GBM).
- The solitary nature and intraventricular location of this high-grade glioma were notable.
Implications:
- This case underscores the need for a broad differential diagnosis in patients with third ventricular masses.
- Understanding the clinical and radiological presentation of rare GBM locations is crucial for timely diagnosis and management.
- Further research into the origins and optimal treatment strategies for intraventricular GBM is warranted.