Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosomes in old age: a six year longitudinal study

L F Jarvik, F S Yen, T K Fu

    Human Genetics
    |July 7, 1976
    PubMed
    Summary

    Aging women show a significant increase in hypodiploidy, a type of chromosome abnormality, over time. This longitudinal study confirms that this age-related change in chromosome number is specific to females, not males.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A Point-based Mortality Prediction System for Older Adults with Diabetes.

    Scientific reports·2017
    Same author

    Cancer as a cause of death.

    The Eugenics review·2011
    Same author

    Substance abuse treatment initiation among older adults in the GET SMART program: effects of depression and cognitive status.

    Aging & mental health·2004
    Same author

    Cognitive-behavioral treatment of older veterans with substance abuse problems.

    Journal of geriatric psychiatry and neurology·2000
    Same author

    Portraits of change: case studies from an elder-specific addiction program.

    Journal of geriatric psychiatry and neurology·2000
    Same author

    Production of paired helical filament, tau-like proteins by PC12 cells: a model of neurofibrillary degeneration.

    Journal of neuroscience research·1998

    Area of Science:

    • Gerontology
    • Genetics
    • Cell Biology

    Background:

    • Aneuploidy, an abnormal chromosome number, is observed to increase with age in cross-sectional studies.
    • Previous research suggested a link between aging and increased aneuploidy, but longitudinal data in the very old was lacking.

    Purpose of the Study:

    • To longitudinally investigate age-related changes in aneuploidy in elderly men and women.
    • To confirm or refute cross-sectional findings regarding sex differences in age-related aneuploidy.

    Main Methods:

    • Longitudinal study of 17 elderly twins (11 women, 6 men) with a mean age of 89.7 years.
    • Two examinations approximately 6 years apart.
    • Analysis of chromosomal abnormalities, including hypodiploidy and hyperdiploidy.

    Main Results:

    • Women exhibited a statistically significant increase in hypodiploidy over the 6-year period.
    • This increase in hypodiploidy was widespread among the female subjects, not concentrated in a few individuals.
    • Men showed a non-significant trend of G-group chromosome loss.

    Conclusions:

    • This is the first longitudinal study to confirm that aging women, even in their ninth decade, experience a significant increase in hypodiploidy.
    • The findings highlight a sex-specific pattern of chromosomal instability associated with advanced aging.

    Related Experiment Videos