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Survival after surgical treatment of recurrent pulmonary metastases
A M Groeger1, D Kandioler, M R Mueller
1Department of Cardio-Thoracic Surgery, University of Vienna, Austria.
Objective:
Resection of lung metastases is a generally accepted therapeutic strategy today. This retrospective study was performed in order to estimate the value of an aggressive surgical approach in recurrent metastatic disease of the lung.
Methods:
The survival rates of 42 patients undergoing repeated resectional treatment for recurrent lung metastases (group A) were compared to the outcome of a total of 288 patients after a single surgical intervention for lung metastases (group B). Survival rates and the relative effects of the various prognostic factors were calculated according to Kaplan-Maier and Mantel Cox or Wilcoxon test. Histology of the primary tumors in group A consisted of 18 carcinomas, 22 sarcomas and two melanomas, in group B the distribution was 64% carcinoma, 27% sarcoma and 9% melanoma. The mean follow-up period was 88.5 months for group A and 27 months for group B.
Results:
The overall survival rate for group A was 48% at 5 years and 30% at 10 years, the survival rate for group B was 34% at 5 years.
Conclusion:
Long-term survival rates superior to those after single resectional treatment for lung metastases encourage an aggressive surgical approach for this disease.