Related Experiment Video
Updated: Jul 26, 2026

Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan
Published on: September 7, 2019
Oligosaccharide Le(a)-Le(x): a cell surface marker for carcinomas derived from embryonic endoderm
P L Stranahan1, J LaRoe, R McCombs
1University of Colorado Cancer Center, Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Abstract:
An immunohistochemical evaluation of Le(a)-Le(x) expression by adenocarcinomas of the biliary tree, pancreas, colon and stomach was undertaken as examples of epithelial tumors derived from embryonic endoderm. This complements previous studies showing that Lea-Lex was present on the cell surface of non-small cell lung carcinomas, some non-lung carcinomas, and is a prognostic marker for squamous cell lung carcinomas. All of the tumor specimen evaluated were positive and no expression of Le(a)-Le(x) was detected in derivatives of neural, connective or muscle tissues. These findings indicate that it could be informative to examine the biological significance of Le(a)-Le(x) not only in carcinogenesis but during embryogenesis, as well.
Related Concept Videos
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Selectins
Renewal of Intestinal Stem Cells
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

