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Expression of human endogenous retrovirus ERV3 (HERV-R) mRNA in normal and neoplastic tissues
A C Andersson1, A C Svensson, C Rolny
1Department of Pathology, Uppsala University Hospital, S-751 85 Uppsala, Sweden.
International Journal of Oncology
|February 12, 1998
Abstract:
We investigated the mRNA expression of the human endogenous retrovirus ERV3 (HERV-R) in several normal and corresponding tumor tissues. The env gene of ERV3 is expressed as mRNA in several tissues. Comparison of ERV3 mRNA expression by Northern analyses, revealed a non-systematic variation. Expression was shown to be particularly high in the adrenal gland and some cases of lung cancer. This tissue-tropism should be seen in relation to the high expression previously found in syncytiotrophoblasts in placenta and sebaceous glands of the skin, suggesting profound influences by steroid hormonal regulation.