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Relationship between thyroid hormones and plasma D-dimer levels

R Chadarevian1, E Bruckert, A Ankri

  • 1Service d'Endocrinologie-Métabolisme, Hôpital Pitié Salpétrière, Paris, France.

Thrombosis and Haemostasis
|February 12, 1998
PubMed
Summary
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Low free thyroxine (fT4) levels are linked to a hypercoagulable state in hyperlipidemic patients. This suggests fT4 plays a role in regulating blood clotting and hemostasis in this population.

Area of Science:

  • Endocrinology
  • Hematology
  • Cardiovascular Disease

Background:

  • Hyperlipidemia is a risk factor for coronary heart disease.
  • Thyroid disorders frequently coexist with hyperlipidemia and are linked to hemostatic abnormalities.

Purpose of the Study:

  • To investigate the relationship between free thyroxine (fT4) levels and key hemostatic parameters in hyperlipidemic patients.
  • To determine if fT4 influences coagulation factors like Factor VII (FVIIc), Factor VIII (FVIIIc), D-Dimer (DDI), and Plasminogen Activator Inhibitor type 1 (PAI-1).

Main Methods:

  • Analysis of 472 hyperlipidemic patients, including 40 with primary hypothyroidism.
  • Correlation analysis between fT4 levels and FVIIc, FVIIIc, DDI, and PAI-1.
  • Multivariate regression analysis to assess independence from other factors like age, BMI, gender, and total cholesterol.

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Main Results:

  • A significant negative correlation was observed between fT4 and D-Dimer (DDI) in the overall population (p = 0.0001, r = -0.21).
  • This negative correlation persisted after excluding patients with subnormal fT4 levels (p = 0.0007, r = -0.17).
  • The association between fT4 and DDI was independent of age, BMI, gender, and total cholesterol. Weaker correlations were found with FVIIc, FVIIIc, and PAI-1.

Conclusions:

  • Free thyroxine (fT4) may play a physiological role in maintaining hemostatic balance in hyperlipidemic individuals.
  • Lower fT4 levels are associated with a hypercoagulable state, indicating a potential link between thyroid function and thrombosis risk in this patient group.