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Mutation in the thyroid hormone receptor beta gene (A317T) in a Thai subject with resistance to thyroid hormone
T Sunthornthepvarakul1, K Angsusingha, S Likitmaskul
1Department of Medicine, Rajavithi Hospital, Bangkok, Thailand.
Thyroid : Official Journal of the American Thyroid Association
|February 12, 1998
Abstract:
Analysis of the thyroid hormone receptor beta (TRbeta) gene of a Thai female with the syndrome of resistance to thyroid hormone (RTH) revealed a missense mutation at codon 317, changing the guanine in nucleotide 1234 to an adenine that results in the replacement of the normal alanine (GCT) with a threonine (ACT). The proposita was heterozygous, and this mutation was not present in her parents and her sister, compatible with a neomutation. This is the first report of TRbeta gene mutation causing RTH in an individual of Thai origin.