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Related Experiment Video

Updated: May 10, 2026

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test
08:58

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Published on: April 30, 2019

Serum neutralizing antibody after rabies postexposure prophylaxis

L Corey, M A Hattwick, G M Baer

    Annals of Internal Medicine
    |August 1, 1976
    PubMed
    Summary

    Many individuals receiving postexposure rabies prophylaxis, especially with equine antirabies serum, may not develop sufficient rabies antibody titers. Monitoring antibody levels 30-40 days after treatment is recommended to ensure adequate immunity.

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    In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
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    Published on: May 11, 2020

    Detection of Rabies IgG and IgM Antibodies Using the Rabies Indirect Fluorescent Antibody Test
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    Detection of Rabies IgG and IgM Antibodies Using the Rabies Indirect Fluorescent Antibody Test

    Published on: January 19, 2024

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Public Health

    Background:

    • Postexposure rabies prophylaxis (PEP) is crucial for preventing rabies after potential exposure.
    • Current PEP protocols involve rabies vaccines and sometimes rabies antiserum.
    • Assessing the immunogenicity of different PEP regimens is vital for patient outcomes.

    Purpose of the Study:

    • To evaluate the adequacy of serum neutralizing antibody titers in individuals receiving PEP.
    • To identify factors associated with inadequate immune responses to PEP.
    • To recommend optimal timing for antibody titer assessment in PEP recipients.

    Main Methods:

    • Serum specimens were collected from 177 individuals 30-90 days post-PEP initiation.
    • Neutralizing antibody titers were determined.
    • Outcomes were analyzed based on PEP components, steroid use, and equine antirabies serum dosage.

    Main Results:

    • 92% of individuals receiving only duck embryo vaccine achieved adequate antibody titers.
    • 23% of individuals receiving equine antirabies serum plus duck embryo vaccine had inadequate titers.
    • Steroid use and high doses (>55 lu/kg) of equine antirabies serum were linked to poor antibody response.

    Conclusions:

    • A significant proportion of individuals on PEP may not develop sufficient humoral immunity.
    • Inadequate immune response to PEP increases the risk of rabies, as evidenced by a fatality.
    • Routine antibody titer determination 30-40 days after PEP initiation is advisable to ensure treatment efficacy.