Related Experiment Videos
Transitional cell carcinoma of the urinary tract: radiologic-pathologic correlation
J J Wong-You-Cheong1, B J Wagner, C J Davis
1Department of Radiology, University of Maryland School of Medicine, Baltimore, USA.
Summary
Transitional cell carcinomas (TCCs) affect the urothelium, presenting characteristic imaging findings. These tumors, often irregular masses, vary in presentation depending on location within the genitourinary tract.
Area of Science:
- Urology
- Oncology
- Radiology
Background:
- The urothelium is susceptible to carcinogens, leading to transitional cell carcinomas (TCCs).
- TCCs can occur synchronously or metachronously throughout the genitourinary tract.
- Distinct pathologic and imaging features aid in differentiating TCCs based on their location.
Purpose of the Study:
- To describe the characteristic imaging findings of transitional cell carcinomas (TCCs) in the renal pelvis, ureter, and urinary bladder.
- To differentiate TCC presentations based on anatomical location within the genitourinary tract.
Main Methods:
- Review of imaging features of TCCs in the renal pelvis, ureter, and urinary bladder.
- Correlation of imaging findings with pathologic characteristics of TCCs.
Main Results:
- Transitional cell carcinoma (TCC) typically presents as a slightly irregular, fixed mass on the urothelial surface.
- Renal pelvis TCCs may infiltrate the renal parenchyma while preserving the reniform shape.
- Ureteral TCCs grow slowly, causing gradual lumen expansion and less acute renal colic compared to calculi.
- Focal wall thickening is a common manifestation of ureteral TCC and other urinary tract TCCs.
- Urinary bladder TCCs are most common, usually remaining intraluminal until significantly large.
Conclusions:
- Imaging findings of transitional cell carcinoma (TCC) are specific to its location within the genitourinary tract.
- Understanding these location-specific features is crucial for accurate diagnosis and management of TCCs.