Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subtotal colectomy for refractory pseudomembranous enterocolitis

W C Boyd, L DenBesten

    JAMA
    |January 12, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Rh blood factors; a résumé.

    The Merck report·2010
    Same author

    Forensic immunology.

    The Journal of criminal law and criminology, including the American journal of police science·2010
    Same author

    Specificity of isoagglutinin response following injection of group substances into group O individuals.

    Blood·2010
    Same author

    Spontaneous loss of specificity of absorbed immune hemagglutinating sera.

    Journal of immunology (Baltimore, Md. : 1950)·2010
    Same author

    Decreased antigenicity of coupled hapten-protein antigen resulting from treatment with too much hapten.

    Journal of immunology (Baltimore, Md. : 1950)·2010
    Same author

    Effect of photo-oxidation on isohemagglutinating antibodies.

    The Journal of experimental medicine·2010
    Same journal

    WHO Issues Guidelines for Treating Ebola and Marburg Viruses.

    JAMA·2026
    Same journal

    FDA Approves Additional Naloxone Nasal Spray for Opioid Overdose.

    JAMA·2026
    Same journal

    HIV May Hide in More Cells Than Previously Thought-Here's What That Could Mean for a Cure.

    JAMA·2026
    Same journal

    US Dietary Supplement Use Increasing, Especially in Older Adults.

    JAMA·2026
    Same journal

    Heat Stress From Climate Change Surges Globally.

    JAMA·2026
    Same journal

    Strength Training Linked With Lower Cardiovascular Disease Risk in Women.

    JAMA·2026
    See all related articles

    Pseudomembranous enterocolitis, often caused by antibiotics like clindamycin, may not improve with medication. Surgical intervention, specifically subtotal colectomy with ileostomy, can lead to recovery in severe cases.

    Area of Science:

    • Gastroenterology
    • Surgical Gastroenterology
    • Infectious Diseases

    Background:

    • Antibiotic-associated pseudomembranous enterocolitis (A-APEC) is a serious gastrointestinal condition.
    • Severe A-APEC can be refractory to medical management, including antibiotics and supportive care.
    • Clindamycin and lincomycin hydrochloride monohydrate are known causative agents.

    Observation:

    • Two critically ill patients with A-APEC were described.
    • These patients did not respond to conventional medical and drug therapies.
    • Their condition was life-threatening, necessitating alternative treatment strategies.

    Findings:

    • Both patients underwent subtotal colectomy with ileostomy.
    • Following the surgical intervention, both patients demonstrated complete recovery.

    Related Experiment Videos

  • This suggests surgical management as a viable option for refractory A-APEC.

    • Implications:

    • Subtotal colectomy with ileostomy may be a life-saving option for patients with severe, medically refractory pseudomembranous enterocolitis.
    • This surgical approach offers an alternative when antibiotic therapy and intensive medical support fail.
    • Further research into surgical indications and outcomes for A-APEC is warranted.