Modification of catalase by chondroitin sulfate
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Updated: Oct 30, 2026

Enzymatic Modification and Flow Cytometry Assessment of Yeast Surface Displayed Proteins
Published on: May 30, 2025
A V Maksimenko1, E G Tischenko
1Institute of Experimental Cardiology, Russian Cardiology Research Center, Moscow, Russia. csc@adonis.ias.msk.su
Abstract:
Catalase was chemically modified by sodium chondroitin sulfate using the benzoquinone binding method. Thus, 40-42% of the catalase preparation was modified. Treatment of catalase and superoxide dismutase with benzoquinone-activated chondroitin sulfate results in a bienzymic conjugate with electrophoretically heterogenous composition. The yield of the products and their residual catalytic activity indicate that the method can be used for the preparation of modified catalase and the bienzymic conjugate to study their efficiency in vivo.
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