Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Friedelane triterpenoids from Maytenus macrocarpa

H Chávez1, A Estévez-Braun, A G Ravelo

  • 1Instituto Universitario de Bio-Orgánica, Antonio Gonzalez, Universidad de Laguna, Tenerife, Canary Island, Spain.

Journal of Natural Products
|February 14, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seasonal characterisation of iron-binding ligands in the South Atlantic sector of the Southern Ocean (Scale cruises, 2019).

Marine environmental research·2026
Same author

Trace metal interaction with thermophilic phototrophic anaerobic bacterium Chloroflexus aurantiacus.

Chemosphere·2024
Same author

Global decrease in heavy metal concentrations in brown algae in the last 90 years.

Journal of hazardous materials·2022
Same author

Cost estimation alongside a multi-regional, multi-country randomized trial of antenatal ultrasound in five low-and-middle-income countries.

BMC public health·2021
Same author

Storage and recycling of major and trace element in mangroves.

The Science of the total environment·2021
Same author

CO<sub>2</sub> fluxes in the Northeast Atlantic Ocean based on measurements from a surface ocean observation platform.

The Science of the total environment·2021

Researchers isolated new and known friedelane triterpenoids from Maytenus macrocarpa bark. The new compound showed weak aldose reductase activity but no antitumor effects.

Area of Science:

  • Natural Products Chemistry
  • Phytochemistry
  • Organic Chemistry

Background:

  • Maytenus macrocarpa is a plant source of bioactive compounds.
  • Triterpenoids are a diverse class of natural products with various biological activities.
  • Friedelane triterpenoids are known for their potential pharmacological properties.

Purpose of the Study:

  • To isolate and characterize compounds from Maytenus macrocarpa stem bark exudates.
  • To identify novel triterpenoids and evaluate their biological activities.
  • To contribute to the understanding of the chemical constituents of Maytenus species.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation via spectroscopic methods (NMR, 2D NMR) and chemical evidence.

Related Experiment Videos

  • Biological activity screening, including aldose reductase inhibition and antitumor assays.

    • Main Results:

    • A new friedelane triterpene (compound 1) was isolated.
    • Known compounds identified include friedelin, 3-oxo-29-hydroxyfriedelane, 3-oxofriedelan-25-al, and canophyllol.
    • Compound 1 exhibited weak aldose reductase inhibitory activity.
    • No significant antitumor activity was observed against tested cancer cell lines (P-388, A-549, HT-29, MEL-28).

    Conclusions:

    • The study successfully identified a new friedelane triterpene from Maytenus macrocarpa.
    • The isolated compounds represent a significant chemical profile of the plant's bark exudates.
    • While showing limited aldose reductase activity, the new compound did not demonstrate antitumor potential in the tested assays.