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Related Experiment Videos

Time- and dose-dependent changes in ejection fraction after anthracycline therapy

K A Narahara, J W Singer, J L Ritchie

    Journal of Cardiovascular Pharmacology
    |July 1, 1979
    PubMed
    Summary

    Radionuclide ejection fractions (EFrn) can detect early and chronic cardiac toxicity from anthracyclines like doxorubicin. This noninvasive method monitors heart function during chemotherapy, aiding in dose management.

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    Area of Science:

    • Cardiology
    • Oncology
    • Nuclear Medicine

    Background:

    • Anthracycline chemotherapy, including doxorubicin and daunomycin, can cause dose-related cardiac toxicity, leading to congestive heart failure.
    • Congestive heart failure is a significant limitation in anthracycline therapy, necessitating careful monitoring of cardiac function.

    Purpose of the Study:

    • To evaluate the utility of radionuclide cardiac evaluation, specifically radionuclide ejection fractions (EFrn), in detecting early and cumulative cardiac toxicity associated with anthracycline therapy.
    • To assess the sensitivity of EFrn in identifying drug-induced cardiac changes in patients receiving doxorubicin or daunomycin.

    Main Methods:

    • Fifteen patients undergoing doxorubicin or daunomycin therapy were assessed using radionuclide ejection fractions (EFrn).

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  • Cardiac function was evaluated noninvasively through serial EFrn measurements to detect acute and chronic effects of the chemotherapy drugs.

    • Main Results:

    • Radionuclide ejection fractions (EFrn) detected acute cardiac depression as early as 24 hours after anthracycline administration.
    • A significant correlation (p < 0.001) was observed between cumulative dosage of doxorubicin or daunomycin and reduced EFrn, indicating chronic cardiac depression.

    Conclusions:

    • Noninvasive radionuclide ejection fractions (EFrn) can effectively detect significant cardiac function changes at low cumulative doses of doxorubicin or daunomycin.
    • EFrn serves as a valuable tool for monitoring cardiac function in patients undergoing anthracycline chemotherapy, potentially guiding treatment decisions.