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Severe hindlimb ischemia causes periosteal proliferation in the rat tibia
S Skjeldal1, A Svindland, K Hvaal
1Institute for Surgical Research, National Hospital, Oslo, Norway.
Acta Orthopaedica Scandinavica
|February 14, 1998
Abstract:
In this rat study, we found tibial periosteal hyperplasia and hypertrophy, and appositional new bone formation 3 days after transient hindlimb ischemia. This response was positively correlated to the extent of muscle necrosis, which was increased either by raising the environmental temperature during ischemia or by prolonging the period of ischemia. By changing the temperature from 21 degrees C to 34 degrees C, the area periost in percent of the total tibial area was increased from 5 to 17, and by changing the duration of ischemia from 3 to 5 hours, it increased from 8 to 18.