Related Experiment Videos
Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features
P W Kamphuisen1, J Haan, P C Rosekrans
1Haemostasis and Thrombosis Research Center, Department of Haematology, University Hospital Leiden, The Netherlands.
American Journal of Hematology
|February 14, 1998
Abstract:
We report a 71-year-old man who developed deep-vein thrombosis after major surgery. Coumarin skin necrosis developed after starting oral anticoagulant therapy. An inhibitor to factor V (61 Bethesda units) with lupus-like features was found as well as a low protein C level. The occurrence of these very rare findings indicates that despite profound procoagulant inhibition (factor V inhibition and anticoagulant therapy), hypercoagulation can occur.