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Updated: Jul 30, 2026

Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter
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Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter

Published on: June 15, 2015

Spontaneous closure of ventricular septal defect

L J Krovetz

    The American Journal of Cardiology
    |February 14, 1998
    PubMed

    Insights

    Most ventricular septal defects close spontaneously in children. This study followed 1066 patients, finding 71% experienced spontaneous closure, with few requiring surgery or succumbing to the condition.

    Area of Science:

    • Cardiology
    • Pediatric Medicine
    • Congenital Heart Disease

    Background:

    • Ventricular septal defect (VSD) is a common congenital heart anomaly.
    • Understanding the natural history and outcomes of VSD is crucial for clinical management.

    Purpose of the Study:

    • To investigate the long-term outcomes of patients diagnosed with ventricular septal defect.
    • To determine the rates of spontaneous closure, surgical intervention, and mortality in a VSD cohort.

    Main Methods:

    • A retrospective follow-up study was conducted.
    • One thousand sixty-six (1066) patients with VSD were included in the analysis.
    • Data on closure status, interventions, and survival were collected and analyzed.

    Main Results:

    • Spontaneous closure of the VSD was observed in a significant majority of patients (71%).
    • Operative closure was necessary for 5% of the cohort.
    • A mortality rate of 2.3% was recorded in the studied population.

    Conclusions:

    • Ventricular septal defect frequently exhibits favorable natural progression with high rates of spontaneous resolution.
    • While surgical intervention is sometimes required, the majority of VSD cases have positive outcomes.
    • Early diagnosis and monitoring are essential for managing patients with congenital heart defects like VSD.

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