Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phenformin and lactic acidosis

L A Conlay, J E Loewenstein

    JAMA
    |April 12, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Severe lactic acidosis in patients was strongly linked to phenformin hydrochloride use. High drug levels were observed, and while kidney function could recover, this condition significantly contributed to diabetic metabolic acidosis deaths.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Current practice patterns for adult perioperative transesophageal echocardiography in the United States.

    Anesthesiology·2001
    Same author

    The impact of longer-than-average anesthesia times on the billing of academic anesthesiology departments.

    Anesthesia and analgesia·2001
    Same author

    Caffeine alters plasma adenosine levels.

    Nature·1997
    Same author

    Hypocalcemia due to avid calcium uptake by osteoblastic metastases of prostate cancer.

    The Western journal of medicine·1995
    Same author

    [Propofol suppresses sympathetic activity and inhibits the baroreceptor reflex in waking rats].

    Eksperimental'naia i klinicheskaia farmakologiia·1993
    Same author

    Exercise and neuromodulators: choline and acetylcholine in marathon runners.

    International journal of sports medicine·1992
    Same journal

    WHO Issues Guidelines for Treating Ebola and Marburg Viruses.

    JAMA·2026
    Same journal

    FDA Approves Additional Naloxone Nasal Spray for Opioid Overdose.

    JAMA·2026
    Same journal

    HIV May Hide in More Cells Than Previously Thought-Here's What That Could Mean for a Cure.

    JAMA·2026
    Same journal

    US Dietary Supplement Use Increasing, Especially in Older Adults.

    JAMA·2026
    Same journal

    Heat Stress From Climate Change Surges Globally.

    JAMA·2026
    Same journal

    Strength Training Linked With Lower Cardiovascular Disease Risk in Women.

    JAMA·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Toxicology
    • Internal Medicine

    Background:

    • Phenformin hydrochloride is a medication previously used for managing type 2 diabetes.
    • Lactic acidosis is a serious medical condition characterized by a buildup of lactic acid in the bloodstream.

    Observation:

    • A study observed all patients admitted with severe lactic acidosis over 17 months.
    • All identified patients were concurrently taking phenformin hydrochloride.
    • Elevated serum phenformin concentrations, 4-9 times the usual therapeutic levels, were detected in one patient.

    Findings:

    • Phenformin-associated lactic acidosis was identified as the cause for all severe lactic acidosis cases in the study cohort.
    • Prerenal azotemia was a common comorbidity at admission.

    Related Experiment Videos

  • Patients who survived and had phenformin-associated lactic acidosis showed normal renal function upon discharge.

    • Implications:

    • Phenformin hydrochloride is a significant risk factor for severe lactic acidosis, particularly in diabetic patients.
    • This drug-induced condition contributed substantially to metabolic acidosis mortality in diabetics.
    • Clinical vigilance for phenformin levels and lactic acidosis is crucial in diabetic patients.