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Tissue concentrations after a single-dose, orally administered ofloxacin in patients with diabetic foot infections
E M Kuck1, K P Bouter, J B Hoekstra
1Department of Clinical Pharmacy, Diakonessenhuis, Utrecht, The Netherlands.
Abstract:
We studied the penetration of orally administered ofloxacin at the site of diabetes-related foot infections in patients with a planned debridement of the lesion. A total of nine patients received 800 mg of oral ofloxacin 120 to 150 minutes before surgery. During surgery, vital margin tissue and a serum sample were obtained. Serum and tissue concentrations of ofloxacin were measured. From seven patients sufficient amounts of tissue were obtained. Mean serum concentration was 7.0+/-3.5 mg/liter; mean tissue concentrations was 11.5+/-8.4 mg/kg. Mean serum and tissue concentrations exceed the minimal inhibitory concentration90 (MIC90) of commonly involved pathogens. This indicates that orally administered ofloxacin can be an effective treatment for infected diabetic foot lesions.
Insights
Oral ofloxacin effectively penetrates diabetic foot infections. Mean tissue concentrations exceeded the minimal inhibitory concentration (MIC90) for common pathogens, suggesting efficacy in treatment.
Area of Science:
- Pharmacology and Infectious Diseases
- Diabetic Foot Complications
Background:
- Diabetes-related foot infections are a significant clinical challenge.
- Assessing antibiotic penetration to infection sites is crucial for effective treatment.
Purpose of the Study:
- To evaluate the penetration of orally administered ofloxacin into diabetic foot infection tissues.
- To determine if ofloxacin concentrations at the infection site exceed the minimal inhibitory concentration (MIC90) of relevant pathogens.
Main Methods:
- Nine patients with planned debridement of diabetic foot lesions received 800 mg of oral ofloxacin pre-surgery.
- Serum and tissue samples were collected during surgery.
- Ofloxacin concentrations in serum and tissue were measured.
Main Results:
- Mean serum concentration of ofloxacin was 7.0+/-3.5 mg/liter.
- Mean tissue concentration was 11.5+/-8.4 mg/kg.
- Concentrations in both serum and tissue surpassed the MIC90 for commonly implicated pathogens.
Conclusions:
- Orally administered ofloxacin achieves therapeutic concentrations at the site of diabetic foot infections.
- Ofloxacin demonstrates potential as an effective oral treatment for infected diabetic foot lesions.