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[Tiagabine: a GABA-ergic anti-epileptic drug]
1Servicio de Neuropediatría, Hospital Universitario Marqués de Valdecilla, Santander, España.
Revista De Neurologia
|February 14, 1998
Abstract
Introduction:
Tiagabina (TGB) is a new anti-epileptic drug which inhibits the uptake of GABA by the neurons and glia and prolongs the time GABA remains at the synapse.
Development:
Experimental studies suggested the efficacy of TGB in generalized tonic-clonic crises, in focal crises and in myoclonic crises. This has been confirmed in the clinical trials carried out in patients and after free use of the drug after being put on sale.
Conclusions:
With few pharmacokinetic interactions, TOB is well tolerated by patients of all ages. This makes it a drug wide good prospects in the ever increasing therapeutic arsenal against