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[Candidiasis in kidney transplant patients]
M Moysés Neto1, R S Costa, M A Reis
1Disciplina de Nefrologia, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo.
Revista Da Sociedade Brasileira De Medicina Tropical
|February 14, 1998
Summary
Renal transplant patients frequently developed Candida infections, primarily in the urinary tract, within six months post-transplant. Candidiasis often occurred alongside antibiotic use and bacterial infections, with a notable mortality rate.
Area of Science:
- Nephrology
- Infectious Diseases
- Transplantation Medicine
Background:
- Renal transplant recipients are susceptible to opportunistic infections.
- Candida species are common pathogens in immunocompromised patients.
Purpose of the Study:
- To investigate the prevalence, sites, causative agents, and outcomes of Candida infections in renal transplant patients.
- To identify risk factors associated with candidiasis in this population.
Main Methods:
- Retrospective survey of medical records of 620 renal transplant patients from February 1968 to February 1995.
- Analysis of 107 episodes of candidiasis in 87 patients.
Main Results:
- Overall prevalence of Candida infections was 14.5%.
- Most common sites: urinary tract (51.0%), respiratory tract (26.0%), gastrointestinal tract (15.0%).
- Candida albicans, C. tropicalis, and C. glabrata were the most frequent agents. Infections often occurred within 6 months post-transplant and were associated with prior antibiotic treatment and bacterial infections.
Conclusions:
- Candida infections pose a significant risk to renal transplant recipients, particularly in the early post-transplant period.
- Urinary and respiratory tract infections are most common, frequently linked to antibiotic use and concurrent bacterial infections.
- Prompt diagnosis and management are crucial to reduce morbidity and mortality.