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Related Experiment Videos

Polymer-coated long-circulating microparticulate pharmaceuticals

V P Torchilin1

  • 1Department of Radiology, Massachusetts General Hospital, Charlestown 02129, USA.

Journal of Microencapsulation
|February 17, 1998
PubMed
Summary

Polymer coatings like poly(ethylene glycol) create protective layers on drug carriers, extending their circulation time. This review explores steric protection mechanisms and potential clinical applications for advanced drug delivery systems.

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Area of Science:

  • Biomaterials Science
  • Pharmaceutical Sciences
  • Nanotechnology

Background:

  • Microparticulate drug carriers are crucial for targeted delivery.
  • Long circulation times are essential for effective drug delivery.
  • Surface modification with polymers enhances carrier performance.

Purpose of the Study:

  • To review the field of long-circulating microparticulate drug carriers.
  • To analyze the steric protection mechanism of polymers, focusing on poly(ethylene glycol).
  • To explore alternative polymers and the design of drug carriers with both longevity and targetability.

Main Methods:

  • Review of existing literature on polymer-coated drug carriers.
  • Analysis of macromolecular behavior in solution to explain steric effects.

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  • Examination of biodistribution data for polymer-coated liposomes.
  • Discussion of the balance between polymer-surface interactions and free motion in solution.

    • Main Results:

    • Surface-grafted polymers form 'conformational clouds' that prevent interactions with other macromolecules.
    • The protective effect depends on the balance between polymer-surface anchoring and polymer chain mobility.
    • Alternative polymers to poly(ethylene glycol) can be used for steric protection.
    • Differences in steric protection exist between liposomes and other nanoparticles/micelles.

    Conclusions:

    • Steric protection is a key strategy for developing long-circulating drug carriers.
    • Understanding polymer behavior is crucial for designing effective drug delivery systems.
    • Further research into combining longevity and targetability holds significant clinical potential.