Electrokinetic chromatography without electroosmotic flow

This review summarizes the various aspects of conducting electrokinetic chromatography in coated columns with suppressed electroosmotic flow. The specific features of the technique will be presented and the potential applications explored. The equations of migration, resolution and zone spreading for neutral solutes will be presented, compared, and contrasted with those of conventional electrokinetic chromatography in bare-silica columns. The principle of separation is the same in electrokinetic chromatography with or without electroosmotic flow; however, there are many significant differences that will be highlighted.