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Effects of cholecystokinin tetrapeptide on respiratory function in healthy volunteers
J Bradwejn1, J M LeGrand, D Koszycki
1Department of Psychiatry and Meakins-Christie Laboratories, McGill University, Montreal, Canada. jbradwejj@rohcg.on.ca
Objective:
The authors evaluated respiratory response to cholecystokinin tetrapeptide (CCK-4) in healthy volunteers.
Method:
Subjects were randomly assigned to either a CCK-4 (N = 15) or placebo (N = 15) challenge under double-blind conditions.
Results:
Dyspnea was reported by all of the subjects who received CCK-4 but only one subject who received placebo. CCK-4 caused a significant increase in tidal volume and minute ventilation but had no effect on breathing frequency. Placebo had no effect on any of the respiratory measures.
Conclusions:
These data indicate that the behavioral effects of CCK-4 are accompanied by changes in respiration in healthy volunteers.