Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioequivalence of Drugs: Drugs with Multiple Indications

Bioequivalence of Drugs: Drugs with Multiple Indications

The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

Nursing Evaluation

Nursing Evaluation

The evaluation stage signals the end of the nursing process. The nurse gathers evaluative data to assess whether or not the patient has attained the expected results. Whereas the nurse collects data in the nursing assessment to identify the patient's health concerns, the evaluation stage data determines if the indicated health issues are resolved. Evaluative data collection includes two sections: the data acquired to evaluate patient outcomes and the time criteria for data collection.

Pharmacokinetic Models: Comparison and Selection Criterion

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.

Bioequivalence: Overview

Bioequivalence: Overview

Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

Nursing Interventions II: Selecting and Classifying the Nursing Interventions

Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[The mechanism of glucose intolerance in patients with Graves' disease].

Nihon Naibunpi Gakkai zasshi·1992

Same author

Prognostic factor of telecobalt therapy for early glottic carcinoma.

Cancer·1992

Same author

Vasodilator action of guinea pig vasoactive intestinal polypeptide (VIP): comparison with common mammalian VIP.

Regulatory peptides·1992

Same author

Generalized resistance to thyroid hormone (GRTH) in a family: case studies.

Endocrinologia japonica·1992

Same author

[Diagnosis of respiratory system diseases using radio isotopes].

Nihon Kyobu Shikkan Gakkai zasshi·1992

Same author

A hyperpolarizing response induced by glutamate in mouse cerebellar Purkinje cells.

Neuroscience research·1992

Same journal

[A Case of Pulmonary Epithelioid Hemangioendothelioma Associated with Multiple Cancers].

Gan to kagaku ryoho. Cancer & chemotherapy·2026

Same journal

[Long-Term Survival in Three Cases with Pulmonary Metastases from Colorectal Cancer Given Low-Dose S-1 Under a Regimen Combining a Carbohydrate-Restricted Ketogenic Diet, Metformin, Vitamin D, Eicosapentaenoic Acid, and Other Complementary Therapies].

Gan to kagaku ryoho. Cancer & chemotherapy·2026

Same journal

[Preventive Effect of Saline Eye Wash for Eye Symptoms Due to High-Dose and Intermediate-Dose Cytarabine Therapy].

Gan to kagaku ryoho. Cancer & chemotherapy·2026

Same journal

[Examination of Factors Affecting the Efficacy of Naldemedine Tosilate Tablets for Opioid-Induced Constipation].

Gan to kagaku ryoho. Cancer & chemotherapy·2026

Same journal

[Recent Advances in the Treatment of HER2-Altered Solid Tumors].

Gan to kagaku ryoho. Cancer & chemotherapy·2026

Same journal

[BRAF-Mutant Solid Tumor].

Gan to kagaku ryoho. Cancer & chemotherapy·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 9, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

[Clinical evaluation based on cost-effectiveness]

T Inoue¹, T Inoue

¹Dept. of Radiation Oncology, Osaka University Medical School.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|February 17, 1998

Summary

This summary is machine-generated.

High dose rate (HDR) brachytherapy offers comparable survival and local control rates to medium dose rate (MDR) and low dose rate (LDR) brachytherapy for cervical and tongue cancers, respectively. HDR brachytherapy also presents a more cost-effective treatment option, especially for patients treated as outpatients.

More Related Videos

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

Related Experiment Videos

Last Updated: Jan 9, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

Area of Science:

Oncology
Radiation Oncology
Medical Economics

Background:

Brachytherapy is a crucial treatment modality for various cancers.
Evaluating treatment efficacy requires considering both clinical outcomes and economic impact.

Purpose of the Study:

To compare the clinical and economic effectiveness of high dose rate (HDR) brachytherapy with medium dose rate (MDR) and low dose rate (LDR) brachytherapy.
To assess HDR brachytherapy in Phase III clinical trials for cervical and tongue cancers.

Main Methods:

Two Phase III clinical trials were conducted comparing HDR brachytherapy with MDR brachytherapy for cervical cancer and LDR brachytherapy for tongue cancer.
Clinical outcomes (survival, local control) and economic factors (total cost, admission days) were evaluated.

Main Results:

For cervical cancer, HDR brachytherapy showed equivalent survival rates to MDR brachytherapy, with lower average total costs (1.47 million yen vs. 1.58 million yen) and fewer admission days (63).
For tongue cancer, HDR brachytherapy demonstrated similar local control rates to LDR brachytherapy, with reduced average total costs (780 thousand yen vs. 830 thousand yen) and fewer admission days (34).
HDR brachytherapy offers potential cost savings and reduced hospital stays, particularly for outpatient treatments.

Conclusions:

HDR brachytherapy is a cost-effective alternative to MDR and LDR brachytherapy for cervical and tongue cancers, respectively.
The study highlights the importance of considering both medical efficacy and cost-effectiveness in treatment decisions.
HDR brachytherapy can be a financially advantageous option for patients living near treatment centers, enabling outpatient care.