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The relationship between multiple intrathyroidal involvement in papillary thyroid carcinoma and chronic non-specific
K Asanuma1, A Sugenoya, Y Kasuga
1Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Cancer Letters
|February 17, 1998
Summary
Multiple intrathyroidal involvement (MII) is more common in papillary thyroid carcinoma patients with chronic non-specific thyroiditis (CT). This suggests intraglandular metastases may cause MII in CT thyroid cancer.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy.
- Chronic non-specific thyroiditis (CT) is an inflammatory condition of the thyroid gland.
- Multiple intrathyroidal involvement (MII) refers to the presence of multifocal disease within the thyroid.
Purpose of the Study:
- To investigate the relationship between multiple intrathyroidal involvement (MII) and chronic non-specific thyroiditis (CT) in patients with papillary thyroid carcinoma (PTC).
Main Methods:
- Retrospective analysis of 69 patients with papillary thyroid carcinoma who underwent subtotal or total thyroidectomy.
- Comparison of the incidence of MII in patients with and without CT.
- Assessment of MII in the affected thyroid lobe in patients with CT.
Main Results:
- The overall incidence of MII was significantly higher in PTC patients with CT compared to those without CT (P = 0.0012).
- The incidence of MII in the affected lobe was also significantly higher in PTC patients with CT (P = 0.0425).
Conclusions:
- Chronic non-specific thyroiditis is associated with a higher incidence of multiple intrathyroidal involvement in papillary thyroid carcinoma.
- The increased MII in the affected lobe in CT cases is potentially due to intraglandular metastases, differentiating it from Hashimoto's thyroiditis.
- These findings may have implications for surgical planning and understanding thyroid cancer behavior in the context of inflammation.