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[Demonstration of plaque development in multiple sclerosis using magnetisation transfer ratio images and protein
A Gass1, C A Davie, G J Barker
1Multiple Sclerosis NMR Research Unit Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, Grossbritannien.
Abstract:
We investigated a patient with secondary progressive Multiple Sclerosis during an acute relapse and after 6 months using several Magnetic Resonance methods. Conventional Magnetic Resonance images demonstrated at the time of relapse a large gadolinium enhancing lesion. Using proton spectroscopy and Magnetisation Transfer images heterogeneous changes suggestive of oedematous swelling peripherally, and active myelin destruction centrally were demonstrated in the acute phase. After clinical recovery there was marked resolution of acute inflammatory Magnetic Resonance abnormalities and recovery of MR tissue parameters. In comparison with conventional Magnetic Resonance Imaging Magnetisation Transfer Imaging and Proton Spectroscopy provide improved characterisation of pathological changes in MS.