Related Experiment Video
Updated: Aug 17, 2026
Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
Published on: May 28, 2021
Toxic epidermal necrolysis--a retrospective study
S Criton1, K Devi, P K Sridevi
1Department of Dermato-Venereology, Medical College Hospital, Thrissur, Kerala, India.
Background:
Toxic epidermal necrolysis (TEN) is a severe, idiosyncratic, exfoliative disease of the skin and mucous membranes. The treatment of this condition is controversial. High-dose corticosteroid therapy has been the most commonly advocated treatment, but, more recently, this has changed to a no-steroid protocol. These conflicting treatments prompted us to evaluate retrospectively our protocol.
Methods:
The patients admitted to the hospital from 1989 to 1995 with a clinical diagnosis of TEN were included in the study. These patients were given systemic steroids, prophylactic antibiotic, and supportive measures.
Results:
The patients belonged to both sexes with an average age of 34 years. The average area of involvement was 85.62%. All the patients made an uneventful recovery without any evidence of sepsis.
Conclusions:
Treatment with systemic steroids is useful in the management of TEN, and there is no need for a burn care center.
