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Nosocomial Candida glabrata colonization: an epidemiologic study

J A Vazquez1, L M Dembry, V Sanchez

  • 1Department of Internal Medicine, Wayne State University School of Medicine, and Veterans Administration Medical Center, Detroit, Michigan 48201, USA. JVAZQUEZ@oncgate.roc.wayne.edu

Journal of Clinical Microbiology
|February 18, 1998
PubMed
Summary

Nosocomial pathogen Candida glabrata acquisition in hospitals is linked to extended stays and prior antibiotic use. Environmental surfaces may serve as a source for patient infections, suggesting indirect transmission routes.

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Hospital Epidemiology

Background:

  • Candida glabrata is an emerging nosocomial pathogen with poorly understood epidemiology.
  • Understanding the transmission dynamics of C. glabrata is crucial for infection control in healthcare settings.

Purpose of the Study:

  • To investigate the epidemiology and risk factors for nosocomial acquisition of Candida glabrata.
  • To determine potential sources of C. glabrata transmission within a university hospital.

Main Methods:

  • Prospective study of 98 patients in intensive care and bone marrow transplant units.
  • Environmental and hospital personnel sampling.
  • Strain delineation using restriction enzyme analysis.

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Main Results:

  • 17% of patients acquired C. glabrata post-admission.
  • Prolonged hospitalization and prior antimicrobial use were significant risk factors.
  • Identical C. glabrata strains were found on environmental surfaces and in patients, suggesting environmental contamination and indirect transmission.

Conclusions:

  • Nosocomial acquisition of C. glabrata is possible, with environmental surfaces potentially serving as a reservoir.
  • Indirect contact transmission, facilitated by hospital environment, is a likely route for C. glabrata spread.
  • Hospital infection control strategies should consider environmental cleaning and antimicrobial stewardship.