Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrosating agents: is peroxynitrite a likely candidate?

D L Williams1

  • 1Department of Chemistry, University of Durham, United Kingdom.

Nitric Oxide : Biology and Chemistry
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat.

Endocrinology·2003
Same author

Fees for RCVS members retired ... and new.

The Veterinary record·2003
Same author

Use of punctal occlusion in the treatment of canine keratoconjunctivitis sicca.

The Journal of small animal practice·2002
Same author

Clinical pathology accreditation: standards for the medical laboratory.

Journal of clinical pathology·2002
Same author

Direct NO group transfer from S-nitrosothiols to iron centres.

Chemical communications (Cambridge, England)·2002
Same author

Scavenger receptor class B type I affects cholesterol homeostasis by magnifying cholesterol flux between cells and HDL.

Journal of lipid research·2001
Same journal

The Effects of Nitrate and Nitrite Supplementation on Mitochondrial Respiration in Permeabilized Muscle Fibres in Young Healthy Adults.

Nitric oxide : biology and chemistry·2026
Same journal

Hydrogen sulfide biology comes of age: Perspectives from the 8th International Conference on H<sub>2</sub>S in biology and medicine.

Nitric oxide : biology and chemistry·2026
Same journal

Inhaled nitric oxide for reducing major adverse events requiring intensive life support in adults undergoing cardiac surgery with cardiopulmonary bypass: protocol for a phase III, double-blind, multicenter randomized controlled trial (NORISC Trial).

Nitric oxide : biology and chemistry·2026
Same journal

The 8th World Congress on Hydrogen Sulfide in Biology and Medicine, Fribourg, Switzerland, July 1-3, 2026.

Nitric oxide : biology and chemistry·2026
Same journal

Photolysis of solid-state S-nitrosoglutathione: Mechanism and kinetics of nitric oxide release.

Nitric oxide : biology and chemistry·2026
Same journal

The interactions of nitric oxide with intracellular redox status and the influence of molecular hydrogen.

Nitric oxide : biology and chemistry·2026
See all related articles

Peroxynitrite is unlikely to directly cause nitrosation. However, its decomposition products, like nitrogen oxides, can lead to low yields of nitrosation products through radical or electrophilic pathways.

Area of Science:

  • Chemistry
  • Biochemistry
  • Nitrosation Reactions

Background:

  • Electrophilic and free radical nitrosation reagents and mechanisms are well-established.
  • Peroxynitrite and peroxynitrous acid are implicated in biological processes, necessitating an understanding of their reactivity.

Purpose of the Study:

  • To evaluate the potential of peroxynitrite/peroxynitrous acid as a nitrosating species.
  • To explain the formation of nitrosation products when peroxynitrite is present.

Main Methods:

  • Review of existing literature on nitrosation reagents and mechanisms.
  • Theoretical consideration of peroxynitrite's reactivity and decomposition pathways.

Main Results:

  • Direct nitrosation by peroxynitrite is not expected under conventional conditions.

Related Experiment Videos

  • Low yields of nitrosation products can be explained by the involvement of nitrogen oxide decomposition products of peroxynitrite (NO, N2O3, NO2, N2O4).
  • Nitric oxide generation from S-nitrosothiols via copper(I) mediation is also discussed.

    • Conclusions:

    • Peroxynitrite itself is not a direct nitrosating agent.
    • Nitrosation observed in the presence of peroxynitrite likely occurs via its decomposition products, acting through radical or electrophilic pathways.
    • The findings contribute to understanding nitrogen oxide chemistry in biological and chemical systems.