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Oral lichenoid drug eruptions
1Department of Oral Surgery, Oral Medicine and Oral Pathology, School of Dental Science, Trinity College Dublin 2, Ireland.
Oral Diseases
|June 1, 1997
Summary
Fewer drugs cause oral lichenoid eruptions than skin ones. Histology and immunology can't reliably distinguish oral lichenoid drug eruptions from similar conditions like oral lichen planus or GVHD.
Area of Science:
- Oral medicine
- Dermatology
- Pharmacology
Background:
- Oral lichenoid drug eruptions (OLDE) are less frequently reported than cutaneous forms.
- Identifying causative drugs and understanding OLDE features is crucial for diagnosis and management.
Purpose of the Study:
- To identify drugs causing OLDE and review their clinical, histological, and immunological features.
- To compare OLDE with oral lichen planus, amalgam contact lesions, and graft-versus-host disease (GVHD).
Main Methods:
- Literature search of Ovid Medline (1966-1996) and relevant references (1940-1996).
- Critical examination of papers for verifiable OLDE and drug withdrawal effects.
- Recording of clinical, histological, and immunological data.
Main Results:
- Fewer drugs reported for oral vs. cutaneous lichenoid eruptions.
- Histology and immunology are unreliable for differentiating OLDE from oral lichen planus, amalgam contact lesions, and GVHD.
- OLDE may share histological features with oral discoid lupus erythematosus.
Conclusions:
- Standardized international protocols are needed to gather substantial information on OLDE.
- Further research could enhance understanding of OLDE mechanisms.