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Related Experiment Videos

Helical structure of human native collagen

T Manebe, Y Kikkawa

    Archives of Pathology & Laboratory Medicine
    |May 1, 1976
    PubMed
    Summary

    This study reveals an unusual helical filamentous structure in lung fibroleiomyoma collagen. These findings offer new insights into collagen organization and cross-linking in human tumors.

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    Area of Science:

    • Pulmonology
    • Oncology
    • Biochemistry

    Background:

    • Fibroleiomyomas are rare lung tumors.
    • Understanding tumor collagen structure is crucial for diagnosis and treatment.

    Observation:

    • A lung fibroleiomyoma specimen from a 40-year-old man was examined using light and electron microscopy.
    • Unusual collagen structures were observed within the tumor tissue.

    Findings:

    • The collagen displayed a filamentous helical structure, with filaments measuring 50 Angstroms in diameter.
    • Most fibrils lacked periodicity, while some exhibited a 700 A periodicity.
    • Periodically structured fibrils were smaller in diameter than non-periodic ones.

    Implications:

    • Suggests a helical native collagen structure and potential weak tropocollagen cross-linking in this tumor.
    • Represents the first report of helical filamentous collagen structure in human tumor material.
    • May inform future research on tumor microenvironment and collagen abnormalities.

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