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Related Experiment Videos

Clinical review 92: Phytoestrogens

A L Murkies1, G Wilcox, S R Davis

  • 1Jean Hailes Centre, Clayton, Victoria, Australia.

The Journal of Clinical Endocrinology and Metabolism
|February 19, 1998
PubMed
Summary

Phytoestrogens, plant compounds found in foods, show physiological effects in humans. They may benefit cardiovascular health and potentially aid in cancer prevention, warranting further research.

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Area of Science:

  • Nutritional Science
  • Endocrinology
  • Human Physiology

Background:

  • Phytoestrogens are plant-derived compounds with estrogen-like biological activity.
  • Their intake, sources, and effects on human health are of significant research interest.
  • Previous literature reviews have explored their role in various physiological processes.

Purpose of the Study:

  • To comprehensively review the literature on phytoestrogens from 1975-1996.
  • To assess food sources, potency, population intakes, and biological effects of phytoestrogens in humans.
  • To evaluate the role of phytoestrogens in female reproduction, cardiovascular disease, osteoporosis, and cancer.

Main Methods:

  • Literature search of the MEDLINE database (1975-1996).
  • Inclusion of over 600 articles covering phytoestrogen metabolism and effects.
  • Assessment of epidemiological, case-control, cohort, randomized trials, review articles, human cell line, and animal studies.

Main Results:

  • Phytoestrogens demonstrate significant physiological effects in humans.
  • Mild estrogenic effects were observed in postmenopausal women.
  • Benefits were noted for hypercholesterolemia, and data suggest a role in cancer prevention.

Conclusions:

  • Phytoestrogens exert measurable physiological effects in humans.
  • Evidence supports their potential benefits for cardiovascular health and postmenopausal symptoms.
  • Further investigation into phytoestrogens for cancer prevention is encouraged based on current data.

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