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Related Experiment Videos

Neural crest cell contribution to the developing circulatory system: implications for vascular morphology?

M Bergwerff1, M E Verberne, M C DeRuiter

  • 1Department of Anatomy and Embryology, Leiden University Medical Centre, The Netherlands.

Circulation Research
|February 19, 1998
PubMed
Summary

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Neural crest cells (NCCs) are crucial for vascular development, differentiating into smooth muscle cells and contributing to artery formation. Their distribution in chick embryos reveals specific patterns influencing vascular morphogenesis.

Area of Science:

  • Developmental Biology
  • Vascular Biology
  • Cell Biology

Background:

  • Neural crest cells (NCCs) are multipotent cells originating from the ectoderm.
  • Vascular morphogenesis involves complex cell-cell interactions and differentiation processes.

Purpose of the Study:

  • To investigate the distribution and role of NCCs in the developing chick vascular system.
  • To correlate NCC patterns with smooth muscle cell differentiation and vascular morphogenesis.

Main Methods:

  • Long-term lineage tracing using quail-chick chimera techniques.
  • Premigratory NCC infection with a replication-incompetent retrovirus (LacZ reporter).
  • Immunohistochemistry for cell identification and localization.

Main Results:

Related Experiment Videos

  • NCC deposition is influenced by pharyngeal arterial positional information.
  • NCCs differentiate into smooth muscle cells, adventitial fibroblasts, and media/intima cells.
  • Specific arteries (aortic arch, pulmonary arch, brachiocephalic, carotid) are NCC-derived; others are not.
  • NC-derived vessels show distinct cellular and elastic fiber composition.

Conclusions:

  • NCCs are essential contributors to the cellular constitution of specific arteries.
  • NCCs play a significant role in smooth muscle cell differentiation and vascular development.
  • Vessel morphology is closely linked to the origin of its cellular components (NCC vs. mesoderm).