Induction chemotherapy and radiotherapy to avoid mastectomy in stage IIA-IIIA breast cancer
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Updated: Oct 30, 2026
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
K A Hartmann1, I Waap, W Audretsch
1Academic Medical Center, University of Amsterdam, Department of Radiotherapy, P.O. Box 22700, DE Amsterdam, 1100, The Netherlands.
Abstract:
The aim of the presented protocol was to investigate tumour remission and breast conservation rates with and without flap supported surgery after preoperative chemotherapy, radiotherapy and hyperthermia. 101 patients with stage IIA-IIIA breast cancers were initially treated with chemotherapy, radiotherapy and hyperthermia. 96 patients underwent salvage surgery. Complete pathologic response was not related to tumour diameter at diagnosis, the applied chemotherapy regime, number of chemotherapy cycles, overall radiation treatment time and time interval between radiotherapy and surgery. A breast conserving approach was possible in 55 patients (54%). After a median follow-up of 18 months no patient developed an isolated local recurrence.
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