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Infrared spectroscopy: a new frontier in medicine
M Jackson1, M G Sowa, H H Mantsch
1Institute for Biodiagnostics, National Research Council, Winnipeg, Manitoba, Canada.
Biophysical Chemistry
|February 20, 1998
Summary
Biological infrared spectroscopy can be applied to medicine. New instrumental and interpretational methods are being developed for analyzing body fluids and tissues, aiming to provide biodiagnostic information.
Area of Science:
- Biophysical techniques
- Medical diagnostics
- Spectroscopy
Background:
- Biological infrared spectroscopy has advanced significantly in studying isolated molecules.
- Other biophysical techniques like magnetic resonance have been successfully integrated into medical research and practice.
Purpose of the Study:
- To explore the transfer of knowledge from molecular infrared spectroscopy to medical applications.
- To review new infrared (IR) techniques for analyzing biological samples in medical contexts.
Main Methods:
- Development and evaluation of novel IR techniques.
- Instrumental advancements including imaging and spatially localized IR spectroscopy.
- Interpretational procedures for optimizing measurements and biodiagnostic conversion.
Main Results:
- Demonstration of the feasibility of applying IR spectroscopy to complex biological systems.
- Development of methods for both in vitro and in vivo analysis of body fluids and tissues.
- Optimization of IR measurements for conversion into clinically relevant biodiagnostic information.
Conclusions:
- Infrared spectroscopy holds significant potential for medical diagnostics.
- New instrumental and interpretational approaches are crucial for translating IR spectroscopy to clinical practice.
- The Spectroscopy Group in Winnipeg is actively contributing to the advancement of biodiagnostic IR techniques.