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Synthesis and biological evaluation of flavanones and flavones related to podophyllotoxin
A Gonzalez De Peredo1, S Léonce, C Monneret
1Unité Mixte de Recherche Institut Curie-CNRS, Institut Curie, Section de Recherche, Paris, France.
Chemical & Pharmaceutical Bulletin
|February 20, 1998
Abstract:
A series of novel flavonoids comprising structural elements present in the antineoplastic agents podophyllotoxin and etoposide was synthesized. These oxygen-containing analogues of antiproliferative quinolones moderate cytotoxicity towards L1210 and HT-29 cell lines.