Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mutation for survival

S M Rosenberg1

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. smr@bcm.tmc.edu

Current Opinion in Genetics & Development
|February 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens.

Current opinion in microbiology·2001
Same author

The TGV transgenic vectors for single-copy gene expression from the Escherichia coli chromosome.

Gene·2001
Same author

SOS mutator DNA polymerase IV functions in adaptive mutation and not adaptive amplification.

Molecular cell·2001
Same author

Stationary-phase mutation in the bacterial chromosome: recombination protein and DNA polymerase IV dependence.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Evolving responsively: adaptive mutation.

Nature reviews. Genetics·2001
Same author

Adaptive amplification: an inducible chromosomal instability mechanism.

Cell·2000
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Adaptive mutations arise from selection, not Lamarckian inheritance or bacterial sex. These mutations occur genome-wide in stressed cells, with genomic regions influencing their detection.

Area of Science:

  • Microbiology
  • Genetics
  • Evolutionary Biology

Background:

  • Adaptive mutations are crucial for evolution and survival under stress.
  • Previous research debated the mechanisms and origins of adaptive mutations, particularly in bacteria.
  • Controversies included Lamarckian inheritance and the role of bacterial conjugation.

Purpose of the Study:

  • To resolve key controversies surrounding adaptive mutation.
  • To elucidate the genomic distribution and cellular basis of adaptive mutations.
  • To investigate the role of DNA repair mechanisms in adaptive mutagenesis.

Main Methods:

  • Analysis of adaptive mutations in a well-characterized model system.
  • Genome-wide mutation profiling of stressed bacterial subpopulations.

Related Experiment Videos

  • Investigation of mismatch repair activity during stationary phase.

    • Main Results:

    • Adaptive mutations are not Lamarckian and do not originate from bacterial sex.
    • Mutations occur genome-wide within a specific subpopulation of stressed cells.
    • Genomic 'hot' and 'cold' regions influence mutation detection rates.
    • Mismatch repair is limited during the stationary phase.

    Conclusions:

    • Adaptive mutations arise from selection acting on spontaneous mutations in a hypermutable subpopulation.
    • Genomic architecture and repair mechanisms significantly impact the observed patterns of adaptive mutation.
    • Findings clarify fundamental aspects of evolutionary adaptation and bacterial genetics.