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APUD cells in normal and hyperplastic prostates

L Pollice, L Resta, G Simone

    La Ricerca in Clinica E in Laboratorio
    |July 1, 1979
    PubMed
    Summary
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    Argyrophilia and argentaffinity in prostate tissues reveal differences between normal and hyperplastic glands. APUD (amine precursor uptake and decarboxylation) cells may play roles in prostate growths.

    Area of Science:

    • Urology
    • Cell Biology
    • Histopathology

    Background:

    • Amine precursor uptake and decarboxylation (APUD) cells possess argyrophilia and argentaffinity.
    • These properties are fundamental to APUD cell identification and function.

    Purpose of the Study:

    • To investigate argyrophilia and argentaffinity in normal and hyperplastic prostate tissues.
    • To explore the potential role of APUD cells in prostate hyperplastic and neoplastic conditions.

    Main Methods:

    • Examination of 50 normal and hyperplastic prostate specimens (autopsy and surgical).
    • Histochemical staining for argyrophil and argentaffin granules.
    • Analysis of cellular distribution and localization.

    Main Results:

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    • Normal prostate epithelia showed 62% argyrophil-positive granules.
    • Hyperplastic glands exhibited a lower positivity rate of 44% for argyrophil granules.
    • Argentaffin-positive cells were identified in 12% of hyperplastic surgical cases, often along the basal membrane.

    Conclusions:

    • Findings suggest altered expression of argyrophilia in prostate hyperplasia.
    • The presence and distribution of APUD cells warrant further investigation in prostate cancer and associated syndromes.
    • APUD cells may be implicated in the pathogenesis of prostate carcinoid tumors (apudomas).