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Related Experiment Videos

Alanyl-aminopeptidase activity decrease in cerebrospinal fluid of Alzheimer patients

M C Iribar1, J Montes, R Gonzalez Maldonado

  • 1Department of Biochemistry, School of Medicine, University of Granada, Spain.

Dementia and Geriatric Cognitive Disorders
|February 20, 1998
PubMed
Summary
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Alzheimer

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Alzheimer disease (AD) is a progressive neurodegenerative disorder.
  • Protein dysfunction is implicated in AD pathogenesis.
  • Amino acid metabolism and enzyme activity may be altered in AD.

Purpose of the Study:

  • To investigate amino acid concentrations and aminopeptidase activities in Alzheimer patients.
  • To correlate these biochemical parameters with disease severity and duration.

Main Methods:

  • Analysis of amino acid levels in plasma and cerebrospinal fluid (CSF).
  • Assay of aminopeptidase activities in plasma and CSF.
  • Correlation analysis with cognitive impairment (Mini Mental State Examination), disease duration, and age.

Main Results:

Related Experiment Videos

  • No significant changes in amino acid concentrations in CSF or plasma of AD patients compared to controls.
  • Significantly lower alanyl-aminopeptidase activity in the CSF of AD patients.
  • Elevated plasma/CSF ratio for alanyl-aminopeptidase activity in AD patients.

Conclusions:

  • Alanyl-aminopeptidase activity in CSF may be a potential biomarker for Alzheimer disease.
  • Altered aminopeptidase activity, not amino acid levels, might be linked to protein dysfunction in AD.
  • Further research is needed to elucidate the role of aminopeptidases in AD pathology.