Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beta2-microglobulin in hypertensive pregnancies

P J Saudan1, T J Farrell, M A Brown

  • 1Department of Renal Medicine, St George Hospital, University of New South Wales, Kogarah, Australia.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|February 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A wild rice byproduct as an alternative to wood sawdust for equine bedding: a pilot study evaluating effects on stall air quality.

Journal of equine veterinary science·2026
Same author

Controlled field study investigating effects of 2 methods of enriching moderate-quality maternal colostrum on transfer of passive immunity and well-being of neonatal dairy calves.

Journal of dairy science·2025
Same author

The genomic landscape of familial glioma.

Science advances·2023
Same author

Distinctive gut microbiomes of ankylosing spondylitis and inflammatory bowel disease patients suggest differing roles in pathogenesis and correlate with disease activity.

Arthritis research & therapy·2022
Same author

The P4 study: Subsequent pregnancy maternal physiology after hypertensive and normotensive pregnancies.

Pregnancy hypertension·2021
Same author

Describing the burden of the COVID-19 pandemic in people with psoriasis: findings from a global cross-sectional study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021

Preeclampsia (PE) is linked to higher serum beta2-microglobulin (beta2-m) levels compared to gestational hypertension (GH) and normal pregnancies. This suggests reduced beta2-m filtering in PE, not altered kidney tubule function.

Area of Science:

  • Nephrology
  • Obstetrics
  • Biochemistry

Background:

  • Beta2-microglobulin (beta2-m) is filtered by glomeruli and reabsorbed by renal tubules.
  • Urinary beta2-m indicates proximal tubular dysfunction, while serum beta2-m can reflect glomerular filtration rate.
  • Preeclampsia (PE) often involves renal dysfunction, including impaired glomerular filtration and tubular issues.

Purpose of the Study:

  • To compare serum beta2-m concentration and urinary beta2-m excretion in women with PE, gestational hypertension (GH), and normal pregnancies.
  • To investigate potential differences in renal handling of beta2-m among these groups.

Main Methods:

  • Prospective study of 75 pregnant women: 35 with PE, 22 with GH, and 18 normotensives.
  • Measurements included serum creatinine, serum beta2-m, 24-hour proteinuria, and fractional excretion (FE) of beta2-m.

Related Experiment Videos

Main Results:

  • Women with PE had significantly higher serum beta2-m than those with GH and controls.
  • Serum creatinine levels were similar between PE and GH groups.
  • Fractional excretion of beta2-m was comparable across all three groups (PE, GH, and controls).

Conclusions:

  • Preeclampsia is associated with elevated serum beta2-m, independent of serum creatinine levels.
  • Similar fractional excretion of beta2-m suggests reduced glomerular filtration in PE, rather than altered tubular reabsorption or degradation.
  • Further research is needed to determine the clinical utility of serum beta2-m in managing hypertensive disorders of pregnancy.