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Stereoselection in designed three-helix bundle metalloproteins
M A Case1, M R Ghadiri, M W Mutz
1Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Chirality
|February 21, 1998
Abstract:
The stereochemical consequences of the metal-ion assisted self-assembly of parallel three-helix peptide bundles are investigated. Chiral induction in the self-assembly of systems containing extensive protein secondary structure is compared with the racemic synthesis of short metallopeptides. Isolation and characterization of the individual stereoisomers of an exchange-inert metalloprotein provide structural insights into analogous exchange-labile systems.