Influence of genes associated with the main histocompatibility complex on deoxyribonucleic acid excision repair capacity and bleomycin sensitivity in mouse lymphocytes

In sets of mice congenic at H-2 and upon two backgrounds, and selected according to known differences in strain-specific lifespans, DNA repair efficiency in spleen cells was compared by two techniques: excision repair capacity following UV-irradiation, and bleomycin sensitivity. Significant differences between certain congenic partner sets were noted with both techniques, suggesting that the main histocompatibility complex influences DNA repair capacity.